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KMID : 1134819970260040662
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 4 p.662 ~ p.668
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Growth Inhibitory Effect and Changes in Membrane Phospholipid Fatty Acid Composition on MG - 63 and AZ - 521 Human Cancer Cells by Linoleic Acid
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Lim Sun-Young
Lee Sook-Hee
Lee Seh-Yoon
Park Kun-Young
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Abstract
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Linoleic acid(LA) was examined to evaluate its potential as a chemotherapeutic agent for MG-63 human osteosarcoma and AZ-521 gastric cancer cells. The treatment of LA(0.005% for 6 days) to the MG-63 and AZ-521 cancer cells inhibited growth of the cancer cells by 54% and 52%, respectively as compared to that of the controls. It also exhibited that LA with 0.01% concentration decreased the [³H] thymidine incorporation by more than 90% in the both cancer cells. In additions we observed morphological changes in MG-63 and AZ-521 cells under inverted microscope, and the changes in membrane fatty acid compositions of the cancer cells when LA was added at the level of 0.005%. The treatment with LA revealed that the contents of 16 : 0 and 18 : 0 decreased significantly, but fatty acids that C numbers are more than 20 and unsaturated(20 : 4, 22 : 6, and 24 : 4) increased, concomitantly the morphological changes of the cells were observed.
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KEYWORD
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linoleic acid, human cancer cells, growth inhibition, membrane fatty acids
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